JAK/STAT signaling in diabetic kidney disease
نویسندگان
چکیده
Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and leading cause end-stage renal (ESRD) worldwide. The Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, which out balance in context DKD, acts through a range metabolism-related cytokines hormones. JAK/STAT primary node progression DKD. latest research on helps determine role this pathway factors associated with DKD progression. These include renin–angiotensin system (RAS), fibrosis, immunity, inflammation, aging, autophagy, EMT. This review epitomizes progress understanding complicated explanation etiologies discusses whether it can be potential target for treating It further summarizes inhibitors, natural products, other drugs that are promising how these inhibitors alleviate to explore possible will contribute formulating effective treatment strategies near future.
منابع مشابه
Non-albuminuric Diabetic Kidney Disease in Diabetic Patients: A Review
Introduction: The constantly increasing incidence of type 2 diabetes, probably due to obesity and sedentary life, has led to the increased incidence of macro- and microvascular diabetic complications such as nephropathy. Despite the prompt efforts to develop effective treatments for diabetes and slow the progression of its complications, it is still reported as the most common cause of chronic ...
متن کاملMicroRNAs in Diabetic Kidney Disease
Diabetes and diabetic kidney diseases have continually exerted a great burden on our society. Although the recent advances in medical research have led to a much better understanding of diabetic kidney diseases, there is still no successful strategy for effective treatments for diabetic kidney diseases. Recently, treatment of diabetic kidney diseases relies either on drugs that reduce the progr...
متن کاملBiomarkers in diabetic kidney disease
Diabetes has become a global public health dilemma and will continue to pose a major challenge throughout the 21st century for healthcare providers. The prevalence of diabetes (both diagnosed and undiagnosed) is approximately 14% of the adult population in the USA according to a 2007 census, and this number is estimated to increase to 21–33% by the year 2050 [101]. All-cause mortality attributa...
متن کاملEpigenetics in diabetic kidney disease.
Regulated gene expression by transcription factor networks is critical for normal kidney function. Disruption of these complex networks leads to biochemical aberrations associated with many renal diseases. Epigenetic mechanisms not involving changes in DNA sequence, such as DNA methylation and post-translational modifications of nucleosomal histones, also play a critical role in gene regulation...
متن کاملDiabetic kidney disease
Screening for various medical conditions is believed to be cost effective when it is targeted at vulnerable or susceptible groups. This proposition, it could be argued, is no more appropriate than screening for chronic kidney disease in people with existing diabetes. The prevalence of CKD in the UK general population is probably around 6%; in patients with diabetes it’s closer to 30%.Of course,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2023
ISSN: ['2296-634X']
DOI: https://doi.org/10.3389/fcell.2023.1233259